Modified Dachengqi Tang improves decreased gastrointestinal motility in postoperative esophageal cancer patients, by Xu Zejun et al.

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JTCM-1336
This study investigated the clinical effects of modified Dachengqi Tang (DCQT) on gastrointestinal motility among sixty post-operative oesophageal cancer patients. Following surgery, subjects were randomly assigned to a treatment group, who received DCQT (via nasojejunal tube), or a control group, who received a placebo decoction (saline solution). DCQT was modified to make it less strongly purging and more tonifying in order to reflect the state of post-surgical cancer patients; the decoction consisted of Da Huang (Rhei Radix et Rhizoma) 10g, Mang Xiao (Mirabilitum) 5g, Hou Po (Magnoliae officinalis Cortex) 15g, Zhi Shi (Aurantii Fructus immaturus) 15g, Dang Gui (Angelicae sinensis Radix) 15g, Huang Qi (Astragali Radix) 15g, Chi Shao (Paeoniae Radix rubra) 15g and Wu Yao (Linderae Radix) 10g. Compared with the control group, the time to first bowel sounds and defecation was significantly shorter in the treatment group, who also had significantly less gastric drainage. In addition, postoperative plasma motilin (MTL) was significantly higher and vasoactive intestinal peptide (VIP) significantly lower in the treatment group (both hormones that modulate gastrointestinal motility), compared the control group. The authors conclude that modified DCQT effectively improves gastrointestinal motility in postoperative oesophageal cancer patients by increasing MTL and reducing VIP. [06/15]
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