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Electro-acupuncture (EA) may improve symptoms of anxiety and depression in patients with polycystic ovarian syndrome (PCOS). A Chinese research team assigned 54 patients to verum acupuncture or sham for 16 weeks. In the verum group two sets of acupuncture points were needled alternately. Set one consisted of Zhongji REN-3, Qihai REN-6, bilateral Guilai ST-29, bilateral Sanyinjiao SP-6, bilateral Yinlingquan SP-9, bilateral Hegu L.I.-4 and Baihui DU-20, while set two involved bilateral Tianshu ST-25, bilateral Guilai ST-29, Zhongji REN-3, Qihai REN-6, bilateral Sanyinjiao SP-6, bilateral Taichong LIV-3, bilateral Neiguan P-6, Baihui and DU-20.The control group received needling at four points (two on the shoulders and two on the upper arm) at locations anatomically remote from verum acupuncture needling sites. Points in the verum group were stimulated at low frequency (2 Hz), while in the sham group the needles were connected to the machine which set at an intensity of zero. After the 16-week intervention, anxiety and depression scores had decreased significantly from baseline in the acupuncture group and were significantly lower than those of the control group. Significant improvements in domains of mental health, vitality, social functioning, general health and health transition, infertility and body hair were also found after EA. The study authors additionally found suggestions that acupuncture could act on psychological outcomes via its influence on serum neurotransmitter levels. An increase from baseline in serum noradrenalin (NE) and a reduction in serotonin (5-HT) were observed in the acupuncture group, while levels of GABA decreased in both groups. However, there were no significant differences between the two groups in the levels of any neurotransmitters.

Effects of electroacupuncture on anxiety and depression in unmarried patients with polycystic ovarian syndrome: secondary analysis of a pilot randomised controlled trial. Acupunct Med. 2019 Feb;37(1):40-46



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