Effect of Sanhuangyilong decoction plus methotrexate on tumor necrosis factor alpha and interferon gamma in serum and synovial fluid in rheumatoid arthritis patients with symptom pattern of damp heat obstruction

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This study investigated the effect of Sanhuangyilong decoction plus methotrexate (MTX) on Interferon gamma and tumour necrosis factor alpha levels in the serum and synovial fluid of rheumatoid arthritis (RA) patients presenting with damp-heat-obstruction. The composition of Sanhuangyilong decoction is as follows: Huang Qin (Scutellariae Radix) 15g, Huang Lian (Coptidis Rhizoma) 15g, Huang Bai (Phellodendri Cortex) 15g, Qin Jiao (Gentianae macrophyllae Radix) 30g, Wei Ling Xian (Clematidis Radix) 30g, Bai Shao (Paeoniae Radix alba) 30g, Xi Xin (Asari Herba) 6g, Di Long (Pheretima) 10g and Fu Ling (Poria) 30g. After four weeks of treatment the results showed that RA patients with damp-heat-obstruction symptom pattern showed more benefit from the combinations of Sanhuangyilong decoction plus MTX than from MTX alone. [Oct 16]
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Author Liu Defang et al
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