Herb-drug enzyme-mediated interactions and the associated experimental methods: a review

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This paper summarises the different methods used for assessing the interaction between herbs and drugs, including microsomal, cell culture and animal experiments, as well as clinical trials. The authors explain that many herbs interact with drugs through a complex cytochrome P450 and/or P-glycoprotein mechanism, and that co-medication with herbs can result in changes in pharmacological effects of many drugs, and potentially severe side effects. They conclude that when choosing a research method to investigate herb-drug interactions, the properties of the drugs and herbs should be considered. [June 2016]
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Author Li Bo et al
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